Aberrant TDP‐43 phosphorylation: a key wind gap from TDP‐43 to TDP‐43 proteinopathy

TDP‐43 proteinopathy is a kind of neurodegenerative diseases related to the TAR DNA‐binding protein 43‐kDa molecular weight (TDP‐43). The typical include amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), Parkinson's (PD) and so on. As process cannot be blocked or slowed down, these patients have poor quality life prognosis, bring huge burden family society. So far, specific pathogenesis not clear, there no effective preventive measure treatment program for this disease. plays an important role in triggering promoting occurrence progression proteinopathy. hyperphosphorylation undoubtedly factor Hyperphosphorylation can inhibit degradation TDP‐43, aggravate aggregation protein, increase wrong localization cells, enhance cytotoxicity TDP‐43. More more evidences show that Inhibition may one strategies Therefore, article reviews phosphorylation mechanisms.